Dr Shavi Fernando's research sheds light on the effects of melatonin on IVF

Congratulations to Dr Shavi Fernando on completion of his PhD at Monash University.

Shavi conducted a pilot double blind placebo controlled dose-response randomised trial assessing the impact of melatonin on the outcomes of assisted reproductive technology (the MIART trial). 

"I randomised women undergoing their first cycle of IVF to receive an oral placebo or any one of three different doses of melatonin during ovarian stimulation," Shavi said.

"My study found that oral supplementation of melatonin in this population results in a clinically and statistically significant dose-dependent increase in serum and follicular fluid concentrations of melatonin."

"Despite this, there were no similar increases in daytime sleepiness or changes in night time sleep quality; ultrasound markers of ovarian response; or oocyte or embryo number or quality," he said.

Importantly, the pilot study found no significant benefit of melatonin on clinical pregnancy or live birth rates in women undergoing treatment with assisted reproductive technology.

Shavi is currently working clinically in both the public and private sector as a specialist obstetrician and gynaecologist. His PhD and interest in medical education has also helped him secure a role as the Director of curriculum and assessment (Women’s Health) at Monash University. In addition, he is a Training supervisor for FRANZCOG trainees at Monash Health.